To explore the effect of TÎ☤ on hair growth and HF development, the mRNA and protein levels of TÎ☤ and VEGF were detected by real-time PCR and western blotting in control and experimental mice. To study TÎ☤ function, we depilated control and experimental mice and made tissue sections stained with hematoxylin and eosin (H&E. We generated mice that overexpressed TÎ☤ in the epidermis, as well as TÎ☤ global knockout mice, to study the role of TÎ☤ in HF development and explore the mechanism of TÎ☤ on hair growth. Thymosin Beta-4 Induces Mouse Hair Growth.įull Text Available Thymosin beta-4 (TÎ☤ is known to induce hair growth and hair follicle (HF development however, its mechanism of action is unknown. Hair shaft abnormalities can be inherited or acquired, can reflect a local problem or a systemic disease. Clinical and morphological hair abnormalities can be clues to speciï¬c complex disorders. Conclusion Although hair has no vital function, it may serve as an indicator for human health. Anomalies of the hair shaft are separated into those with and those without increased hair fragility. Results While common developmental and structural features are shared in hair follicles and hair shafts.
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All abstracts and full text English-language articles were studied. The search terms were: hair shaft abnormality, Hair loss, Hair fragility. A literature search was performed using PubMed, Scopus and Google Scholar on papers publish from 1990 to 2016. Materials and Methods We conducted a review of all papers published on hair shaft abnormalities. We conducted a review study to assess hair shaft abnormality in children. Hair shaft abnormality will divide structural hair abnormalities into two broad categories - those associated with increased hair fragility and those not associated with increased hair fragility. Hair shaft consists of three major regions: the medulla, cortex and cuticle. Hair Shaft Abnormality in Children: a Narrative Reviewĭirectory of Open Access Journals (Sweden)įull Text Available Background Hair is an ectodermal structure, and its formation is regulated by master genes important in embryology.
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